Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis
نویسندگان
چکیده
This review discusses the rational for further studies of COX-2 inhibitors-NO releaser hybrids (NO-Coxibs) in pharmacological treatment airway inflammation Cystic Fibrosis (CF). Our research group developed several classes NO-Coxibs arthritis, and among them compounds showed an outstanding vivo efficacy good pharmacokinetic properties. The antiinflammatory properties displayed by these during previous screening could, itself, suggest appropriate candidates testing CF.
منابع مشابه
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ژورنال
عنوان ژورنال: European journal of medicinal chemistry
سال: 2021
ISSN: ['0009-4374']
DOI: https://doi.org/10.1016/j.ejmech.2020.112983